RPHR -- Wise et al. 57 (1): 235 Figure 11

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FIG. 11. Estradiol protects against ischemic injury-induced cell death in explant cultures of the cerebral cortex. Cell death, as measured by lactose dehydrogenase (LDH) release, is significantly decreased when explants were cultured in the presence of 17ß-estradiol. However, 17 ${alpha}$ -estradiol failed to protect and ICI182,780, an ER antagonist, blocked the protective actions of 17ß-estradiol. [Reprinted from Wilson ME, Dubal DB, Wise PM 2000 Estradiol protects against injury-induced cell death in cortical explant cultures: a role for estrogen receptors. Brain Res 873:235–242.]