TABLE II Pro-angiogenic Agents

Drug Target Approved or potential use References

Regranex (becaplurmin) Unknown Diabetic foot ulcers (Ortho-McNeil Pharmaceuticals) Fruhstorfer, 2000
SIKVAV Unknown Cardiovascular ischemia prevention Grant and Zukowska, 2000
Angiopoietin I Tie-2 on endothelial cells Cardiovascular ischemia prevention Cascone et al., 2003; Fiedler et al., 2003
Angiopoietin II Tie-2 on endothelial cells Cardiovascular ischemia prevention Fiedler et al., 2003; Zhang et al., 2003
Neuropeptide Y NPY2 Wound healing Grant and Zukowska, 2000; Ekstrand et al., 2003; Lee et al., 2003