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Recent Progress in Hormone Research 58:249-261 (2003)
© 2003 The Endocrine Society

Paired-like Repression/Activation in Pituitary Development

Lorin E. Olson*,{dagger}, Jeremy S. Dasen*, Bong Gun Ju*, Jessica Tollkuhn*,{dagger} and Michael G. Rosenfeld*,{ddagger}

* Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093-0648
{dagger} Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California 92093-0648
{ddagger} Department of Medicine, University of California, San Diego, La Jolla, California 92093-0648

Pituitary gland development is controlled by signals that guide expression of specific combinations of transcription factors that dictate serial determination and differentiation events. One class of factors is paired-like homeodomain factors. Two that have been investigated are the repressor Hex1/Rpx and activator prophet of Pit-1 (Prop-1), which exert selective roles during pituitary development. The opposing actions of these factors provide one aspect of pituitary organogenesis.




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