FIG. 9. Estrogen receptor alpha (ER
) and estrogen receptor beta (ERß) gene expression are differentially modulated after MCAO. (Left panel) ER mRNA was dramatically upregulated in the ipsilateral cortex of oil (vehicle)- and estradiol-treated rats, compared to the contralateral cortex and compared to constitutive levels in both oil- and estradiol-treated sham controls. (Right panel) Estradiol treatment prevented the injury-induced downregulation of ERß mRNA in the ipsilateral cortex. In the absence of estradiol, ERß gene expression declined significantly after injury below sham control constitutive levels. [Reprinted from Dubal DB, Shughrue PJ, Wilson ME, Merchenthaler I, Wise PM 1999 Estradiol modulates Bcl-2 in cerebral ischemia: a potential role for estrogen receptors. J Neurosci 19:6385–6393.]
