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FIG. 6. Model for TNF-{alpha}-induced apoptosis in NOD mouse lymphocytes. The TNF-{alpha} signaling pathway generates an unknown proapoptotic signal. The defect in the activation of NF-{kappa}B prevents induction of the expression of a gene (or genes) that encodes an antiapoptotic factor (or factors), resulting in an increased susceptibility to apoptosis.





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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals