TABLE III Summary of Studies Carried Out by Activating and Inhibiting Wnt Signaling in Purified HSC, by Using Retroviral Transduction of Downstream Mediators
|
Phenotype of cells in vitro |
Transplantation ability in vivo |
|
| Control |
+++ |
+++ |
| Beta-catenin |
++++++ |
++++++ |
| Axin |
+ |
+ |
|
[The relative extent of cell proliferation, while maintaining the surface phenotype of HSCs (Lin-/loc-kit+sca-1+Thy1lo), and their ability to reconstitute the hematopoietic system of lethally irradiated recipient mice are indicated by the frequency of + signs.]
