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FIG. 8. Kinetics of NF-
B-dependent gene expression in epithelial cells. (A) A549 cells. Clustering and heat map analysis of the kinetics of NF-B-dependent gene expression in type II-like alveolar cells following RSV infection. Data represent the mean of three independent time courses analyzed by high-density microarrays. Agglomerative hierarchical clustering was performed on average fluorescence intensity values from three independent experiments using the UPGMA technique. A heat map for each gene for the three independent experimental datapoints is shown at right. The color gradient used is dark gray (minimum value of 5 scaled fluorescence intensity units), light gray (middle value of 5000 scaled units), and white (maximum value of 10,000 scaled units). CYP, cytochrome P; GAGE, melanoma antigen-encoding gene; MGSA, melanoma growth stimulatory activity. [Data from Zhang Y, Luxon BA, Casola A, Garofalo RP, Jamaluddin M, Brasier AR 2001 Expression of RSV-induced chemokine gene networks in lower airway epithelial cells revealed by cDNA microarrays. J Virol 75:9044–9058.]
