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Animal model Phenotype and effects References Hypertensive rat models Cardiac hypertrophy and increased CaMKII expression Hagemann et al., 2001 Spontaneously hypertensive rats Cardiac hypertrophy and increased CaMKII activity Boknik et al., 2001 Coronary artery ligation rabbit Cardiac hypertrophy and increased CaMKII activity Currie et al., 1999 Transverse aortic constricted mice Cardiac hypertrophy and increased CaMKII expression and activity Colomer et al., 2003; Zhang et al., 2003 Calmodulin TG mice Severe cardiac hypertrophy and increased CaMKII activity Gruver et al., 1993; Colomer et al., 2000 CaMKIV TG mice Cardiac hypertrophy through MEF2 activation Passier et al., 2000 CaMKIIB TG mice Cardiac hypertrophy and dilated cardiomyopathy Zhang et al., 2002

Abbreviations: TG, transgenic; MEF, myocyte enhancer factor.

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