(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.
FIG. 4. Concept of selective leptin resistance: there is resistance to the appetite- and weight-reducing actions of leptin but preservation of the sympathetic actions. This phenomenon might explain in part how hyperleptinemia could be accompanied by obesity (partial loss of appetite and metabolic actions of leptin) but still contribute to sympathetic overactivity and hypertension because of preservation of the sympathetic actions of leptin to some organs involved in blood pressure regulation (e.g., kidney).
