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FIG. 7. Resistance to transgenic hyperleptinemia as a result of aging, genetic background, and diet-induced obesity (DIO). (A) At a young age, the body weights of LepTg mice on a mixed genetic background (
) are lower than those of normal mice (
), reflecting lower adiposity, but then start to approach the body weights of normal mice at a later age. (B) Genetic resistance to transgenic hyperleptinemia in LepTg males bred on a mixed genetic background (
) is demonstrated by their normal body weight, compared to WT () and LepTg () mice on the same genetic background. (C) Body weights of high-fat diet-fed C57BL/6J normal () and LepTg () mice show the precipitous DIO of LepTg mice. [(A) Reprinted with permission from Qiu J, Ogus S, Lu R, Chehab FF 2001 Transgenic mice overexpressing leptin accumulate adipose mass at an older, but not younger, age. Endocrinology 142:348–358. Copyright The Endocrine Society; (C) Modified with permission from Ogus S, Ke Y, Qiu J, Wang B, Chehab FF 2003 Hyperleptinemia precipitates diet-induced obesity in transgenic mice overexpressing leptin. Endocrinology 144:2865–2869. Copyright The Endocrine Society.]
