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FIG. 3. Neuroendocrine regulation in the arcuate nucleus (ARC) by LRb signals. In the LRb/POMC neuron in the ARC, the Tyr1138 
STAT3 signal mediates the induction of POMC, which is processed to alpha melanocyte-stimulating hormone (
MSH) to activate anorexia and energy expenditure via the melanocortin receptors, MC3R and MC4R. The function of other LRb/Jak2 signals, such as IRS proteins and phosphatidylinositol 3-kinase (IRS-PI3-K), remain undefined in this neuron. In the ARC LRb/neuropeptide Y (NPY)/AgRP-expressing neuron, STAT3 signaling contributes to the repression of AgRP and the de-repression of melanocortin action, while other signals (possibly including IRS-PI3-K) function to repress NPY, disinhibiting the growth and reproductive axes. Other IRS-PI3-K-mediated signals may include the regulation of membrane potential.
