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FIG. 2. Schematic of the phenotypes of mice lacking or overexpressing 11ß-HSD1 in metabolic tissues. The size of the representations of fat depots reflects the mass observed. Paler liver colours represent fat accumulation. Abbreviations: BP, blood pressure; KO, knockout; Tg, transgenic; PPAR
, peroxisome proliferator-activated receptor gamma; UCP-2, uncoupling protein 2; TNF
= tumor necrosis factor alpha; HSD, hydroxysteroid dehydrogenase; FFA, free fatty acid; CORT, corticosterone.
