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FIG. 5. Signaling pathways downstream of Tie2 activation and the cellular responses they may promote. Abbreviations: PI3, phosphatidylinositol 3; PKB, protein kinase B; PKC, protein kinase C; MAPK, mitogen-activated protein kinase; CREB, cyclic adenosine monophosphate response binding protein; IKK, I kappa B kinase complex; eNOS, endothelial nitric oxide synthase; GSK, glycogen synthase kinase.
